Copper-Catalyzed Trifluoromethylation of N,N-Dialkylhydrazones

Mild and practical: Trifluoromethylation of (hetero)aromatic aldehyde N,N‐dialkylhydrazones was achieved at room temperature by using Togni's trifluoromethylation reagent under CuCl catalysis (see scheme). This simple reaction is believed to occur by a CF3‐radical‐transfer mechanism and yields...

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Veröffentlicht in:	Angewandte Chemie International Edition 2013-05, Vol.52 (20), p.5346-5349
Hauptverfasser:	Pair, Etienne, Monteiro, Nuno, Bouyssi, Didier, Baudoin, Olivier
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehydes Catalysis Chlorofluorocarbons, Methane - chemistry copper Copper - chemistry homogeneous catalysis hydrazones Hydrazones - chemical synthesis Hydrazones - chemistry hypervalent compounds Magnetic Resonance Spectroscopy Methylation Molecular Structure trifluoromethylation
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Beschreibung
Zusammenfassung:	Mild and practical: Trifluoromethylation of (hetero)aromatic aldehyde N,N‐dialkylhydrazones was achieved at room temperature by using Togni's trifluoromethylation reagent under CuCl catalysis (see scheme). This simple reaction is believed to occur by a CF3‐radical‐transfer mechanism and yields useful trifluoromethylated building blocks.
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.201300782