Palladium-Catalyzed Hydrocarboxylation of Alkynes with Formic Acid

Palladium-Catalyzed Hydrocarboxylation of Alkynes with Formic Acid

A palladium‐catalyzed hydrocarboxylation of alkynes with formic acid has been developed. The method provides acrylic acid and derivatives in good yields with high regioselectivity without the need to handle toxic CO gas. Nontoxic: Acrylic acids are an important chemical feedstock. The title reaction...

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Veröffentlicht in:Angewandte Chemie International Edition 2015-05, Vol.54 (21), p.6302-6305
Hauptverfasser: Hou, Jing, Xie, Jian-Hua, Zhou, Qi-Lin
Format: Artikel
Sprache:eng
Schlagworte:
Acrylic acid
Alkynes
Carbon monoxide
carboxylic acids
Derivatives
Feedstock
Formic acid
Handles
palladium
P ligands
synthetic methods
Toxic
Toxicology
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Beschreibung
Zusammenfassung:A palladium‐catalyzed hydrocarboxylation of alkynes with formic acid has been developed. The method provides acrylic acid and derivatives in good yields with high regioselectivity without the need to handle toxic CO gas. Nontoxic: Acrylic acids are an important chemical feedstock. The title reaction provides acrylic acid and derivatives in good yields with high regioselectivities without the need to handle toxic CO gas.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201501054