A R sub(2p)/R sub(1p) Ratiometric Procedure to Assess Matrix Metalloproteinase-2 Activity by Magnetic Resonance Imaging

A R sub(2p)/R sub(1p) Ratiometric Procedure to Assess Matrix Metalloproteinase-2 Activity by Magnetic Resonance Imaging

Parametric MRI: A paramagnetic gadolinium-loaded liposome for the MRI assessment of the activity of matrix metalloproteinase-2 (MMP-2) is described. The assessment relies on a procedure that involves the ratio R sub(2p)/R sub(1p) between the transverse and longitudinal paramagnetic contributions to...

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Veröffentlicht in:Angewandte Chemie International Edition 2013-04, Vol.52 (14), p.3926-3930
Hauptverfasser: Catanzaro, Valeria, Gringeri, Concetta V, Menchise, Valeria, Padovan, Sergio, Boffa, Cinzia, Dastru, Walter, Chaabane, Linda, Digilio, Giuseppe, Aime, Silvio
Format: Artikel
Sprache:eng
Schlagworte:
Assessments
Gadolinium
Liposomes
Magnetic resonance imaging
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Zusammenfassung:Parametric MRI: A paramagnetic gadolinium-loaded liposome for the MRI assessment of the activity of matrix metalloproteinase-2 (MMP-2) is described. The assessment relies on a procedure that involves the ratio R sub(2p)/R sub(1p) between the transverse and longitudinal paramagnetic contributions to the water proton relaxation rate. This method is independent of the total gadolinium concentration.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201209286