Iridium-Catalyzed Direct CH Amidation with Weakly Coordinating Carbonyl Directing Groups under Mild Conditions

An iridium‐catalyzed direct CH amidation of weakly coordinating substrates, in particular of those bearing ester and ketone groups, under very mild conditions has been developed. The observed high reaction efficiency was achieved by the combined use of acetic acid and lithium carbonate as additives...

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Veröffentlicht in:Angewandte Chemie International Edition 2014-02, Vol.53 (8), p.2203-2207
Hauptverfasser: Kim, Jinwoo, Chang, Sukbok
Format: Artikel
Sprache:eng
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Zusammenfassung:An iridium‐catalyzed direct CH amidation of weakly coordinating substrates, in particular of those bearing ester and ketone groups, under very mild conditions has been developed. The observed high reaction efficiency was achieved by the combined use of acetic acid and lithium carbonate as additives. Mild and direct: The iridium‐catalyzed direct CH amidation of weakly coordinating substrates, particularly of those with ester and ketone groups, under very mild conditions has been developed. With the aid of a combined use of acetic acid and lithium carbonate as additives, the reaction proceeded with high efficiency. Cp*=pentamethylcyclopentadienyl.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201310544