Unveiling Latent [alpha]-Iminocarbene Reactivity for Intermolecular Cascade Reactions through Alkyne Oxidative Amination

Unveiling Latent [alpha]-Iminocarbene Reactivity for Intermolecular Cascade Reactions through Alkyne Oxidative Amination

Setting a trap: Described is the development of a metallonitrene-initiated alkyne oxidation cascade with intermolecular trapping of the reactive intermediate with a variety of allyl ethers to provide α-oxyimine products in which new CN, CO, and CC bonds have all been generated (see Scheme; tfacam=tr...

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Veröffentlicht in:Angewandte Chemie International Edition 2013-05, Vol.52 (22), p.5836-5839
Hauptverfasser: Mace, Nina, Thornton, Aaron R, Blakey, Simon B
Format: Artikel
Sprache:eng
Schlagworte:
Alkynes
Cascades
Ethers
Oxidation
Trapping
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Beschreibung
Zusammenfassung:Setting a trap: Described is the development of a metallonitrene-initiated alkyne oxidation cascade with intermolecular trapping of the reactive intermediate with a variety of allyl ethers to provide α-oxyimine products in which new CN, CO, and CC bonds have all been generated (see Scheme; tfacam=trifluoroacetamide).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201301087