Copper(i)-catalyzed diastereoselective hydroxytrifluoromethylation of dienes accelerated by phosphine ligands

Copper(i)-catalyzed diastereoselective hydroxytrifluoromethylation of dienes accelerated by phosphine ligands

A diastereoselective 1,4-hydroxytrifluoromethylation of dienes is catalyzed by copper cyanide-phosphine complexes. This reaction is significantly accelerated by bulky monodentate phosphines, and the discovery enables expedient access to a variety of CF sub(3)-containing allylic alcohol derivatives.

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Veröffentlicht in:Chemical science (Cambridge) 2013-01, Vol.4 (6), p.2478-2482
Hauptverfasser: Lu, Deng-Fu, Zhu, Cheng-Liang, Xu, Hao
Format: Artikel
Sprache:eng
Schlagworte:
Alcohols
Copper
Derivatives
Dienes
Ligands
Phosphines
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Zusammenfassung:A diastereoselective 1,4-hydroxytrifluoromethylation of dienes is catalyzed by copper cyanide-phosphine complexes. This reaction is significantly accelerated by bulky monodentate phosphines, and the discovery enables expedient access to a variety of CF sub(3)-containing allylic alcohol derivatives.
ISSN:2041-6520
2041-6539
DOI:10.1039/c3sc50582k