Oxidative Photoredox-Catalytic Activation of Aliphatic Nucleophiles for C(sp3)-C(sp2) Cross-Coupling Reactions

Oxidative Photoredox-Catalytic Activation of Aliphatic Nucleophiles for C(sp3)-C(sp2) Cross-Coupling Reactions

In the light you will find the road (Led Zeppelin): Visible‐light photoredox catalysis leads the way in overcoming the reactivity limitations of alkyl nucleophiles in cross‐coupling reactions. Iridium‐triggered oxidative photoredox activation of alkyltrifluoroborate or carboxylic acids affords alkyl...

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Veröffentlicht in:Angewandte Chemie International Edition 2014-12, Vol.53 (49), p.13326-13328
Hauptverfasser: Jahn, Emanuela, Jahn, Ullrich
Format: Artikel
Sprache:eng
Schlagworte:
Activation
Aliphatic compounds
amino acids
Carboxylic acids
Catalysis
cross-coupling
Nickel
Nucleophiles
persistent radical effect
photoredox catalysis
Radicals
Roads
Zeppelins
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Beschreibung
Zusammenfassung:In the light you will find the road (Led Zeppelin): Visible‐light photoredox catalysis leads the way in overcoming the reactivity limitations of alkyl nucleophiles in cross‐coupling reactions. Iridium‐triggered oxidative photoredox activation of alkyltrifluoroborate or carboxylic acids affords alkyl radicals, which undergo nickel‐catalyzed cross‐coupling reactions.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201408748