The Catalytic Asymmetric Acetalization

The Catalytic Asymmetric Acetalization

In straitened circumstances: In an asymmetric version of the acid‐catalyzed acetalization of aldehydes, a novel member of the chiral confined Brønsted acid family significantly outperformed previously established catalysts, providing cyclic acetals with excellent enantioselectivity (see scheme; Ar=2...

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Veröffentlicht in:Angewandte Chemie International Edition 2013-04, Vol.52 (16), p.4474-4477
Hauptverfasser: Kim, Ji Hye, Čorić, Ilija, Vellalath, Sreekumar, List, Benjamin
Format: Artikel
Sprache:eng
Schlagworte:
acetalization
Acetals
Acetals - chemical synthesis
Acetals - chemistry
Acids - chemistry
Alcohols - chemistry
Aldehydes
Aldehydes - chemistry
asymmetric catalysis
Asymmetry
Catalysis
Catalysts
confined Brønsted acids
Cyclization
Molecular Structure
organocatalysis
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Beschreibung
Zusammenfassung:In straitened circumstances: In an asymmetric version of the acid‐catalyzed acetalization of aldehydes, a novel member of the chiral confined Brønsted acid family significantly outperformed previously established catalysts, providing cyclic acetals with excellent enantioselectivity (see scheme; Ar=2‐iPr‐5‐MeC6H3).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201300120