Palladium-Catalyzed Oxidative Carbonylation of N-Allylamines for the Synthesis of [beta]-Lactams

Palladium-Catalyzed Oxidative Carbonylation of N-Allylamines for the Synthesis of [beta]-Lactams

[beta]-Lactam scaffolds are considered to be ideal building blocks for the synthesis of nitrogen-containing compounds. A new palladium-catalyzed oxidative carbonylation of N-allylamines for the synthesis of [alpha]-methylene-[beta]-lactams is reported. DFT calculations suggest that the formation of...

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Veröffentlicht in:Angewandte Chemie 2014-02, Vol.126 (9), p.2475-2478
Hauptverfasser: Li, Wu, Liu, Chao, Zhang, Heng, Ye, Keyin, Zhang, Guanghui, Zhang, Wangzheng, Duan, Zhengli, You, Shuli, Lei, Aiwen
Format: Artikel
Sprache:eng ; ger
Schlagworte:
Beta
Carbonyls
Chemistry
Formations
Mathematical analysis
Scaffolds
Synthesis
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Zusammenfassung:[beta]-Lactam scaffolds are considered to be ideal building blocks for the synthesis of nitrogen-containing compounds. A new palladium-catalyzed oxidative carbonylation of N-allylamines for the synthesis of [alpha]-methylene-[beta]-lactams is reported. DFT calculations suggest that the formation of [beta]-lactams via a four-membered-ring transition state is favorable. [PUBLICATION ABSTRACT]
ISSN:0044-8249
1521-3757
DOI:10.1002/ange.201309081