A Chemical Probe for Lysine Malonylation

A Chemical Probe for Lysine Malonylation

Tag! You′re it! MalAM‐yne is a chemical reporter for malonylation of lysines within proteins (see scheme), a newly identified posttranslational modification. MalAM‐yne is cell‐permeable and metabolically incorporated into proteins in living cells. Subsequent bioorthogonal tag conjugation allows the...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Angewandte Chemie International Edition 2013-04, Vol.52 (18), p.4883-4886
Hauptverfasser: Bao, Xiucong, Zhao, Qian, Yang, Tangpo, Fung, Yi Man Eva, Li, Xiang David
Format: Artikel
Sprache:eng
Schlagworte:
Alkynes - chemistry
Cellular
Click Chemistry
Conjugation
HeLa Cells
Humans
Lysine
Lysine - chemistry
Lysine - metabolism
lysine malonylation
Malonates - chemistry
metabolic labeling
posttranslational modifications
Profiling
protein modifications
Protein Processing, Post-Translational
Proteins
Proteins - chemistry
Proteins - metabolism
Visualization
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Tag! You′re it! MalAM‐yne is a chemical reporter for malonylation of lysines within proteins (see scheme), a newly identified posttranslational modification. MalAM‐yne is cell‐permeable and metabolically incorporated into proteins in living cells. Subsequent bioorthogonal tag conjugation allows the fluorescent visualization of cellular malonylation and profiling of malonylated proteins.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201300252