BODIPY-Tetrazine Derivatives as Superbright Bioorthogonal Turn-on Probes

BODIPY-Tetrazine Derivatives as Superbright Bioorthogonal Turn-on Probes

The fastest and the brightest: A new design that intimately connects tetrazine to a BODIPY fluorophore enables exceptionally efficient energy transfer and quenching. Upon reaction of the tetrazine, the brightness of the fluorophore increases more than a thousand‐fold, which is a fluorogenic activati...

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Veröffentlicht in:Angewandte Chemie International Edition 2013-07, Vol.52 (27), p.6917-6920
Hauptverfasser: Carlson, Jonathan C. T., Meimetis, Labros G., Hilderbrand, Scott A., Weissleder, Ralph
Format: Artikel
Sprache:eng
Schlagworte:
Activation
Boron Compounds - chemical synthesis
Boron Compounds - chemistry
Brightness
Chemical compounds
Click Chemistry
Derivatives
Energy transfer
Fluorescence
Fluorescent Dyes
fluorescent probes
fluorogenic probes
Molecular Structure
Quenching
Spectrometry, Fluorescence - methods
tetrazines
Tetrazoles - chemistry
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Beschreibung
Zusammenfassung:The fastest and the brightest: A new design that intimately connects tetrazine to a BODIPY fluorophore enables exceptionally efficient energy transfer and quenching. Upon reaction of the tetrazine, the brightness of the fluorophore increases more than a thousand‐fold, which is a fluorogenic activation up to two orders of magnitude greater than previously described.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201301100