Effective Chiral Discrimination of Tetravalent Polyamines on the Compaction of Single DNA Molecules

Normal doughnuts or lots of little ones? Among four stereoisomers of a tetravalent polyamine, the isomer pictured was the most potent at inducing DNA compaction, whereby the DNA molecules adopted a unique morphology of minitoroid clusters. The nonchiral polyamine spermine induced the formation of ty...

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Veröffentlicht in:	Angewandte Chemie International Edition 2013-03, Vol.52 (13), p.3712-3716
Hauptverfasser:	Yoshikawa, Yuko, Umezawa, Naoki, Imamura, Yuki, Kanbe, Toshio, Kato, Nobuki, Yoshikawa, Kenichi, Imanaka, Tadayuki, Higuchi, Tsunehiko
Format:	Artikel
Sprache:	eng
Schlagworte:	amines chirality Circular Dichroism Clusters Deoxyribonucleic acid Discrimination DNA - chemistry DNA structures fluorescence microscopy Formations Isomers Microscopy, Fluorescence Morphology Nucleic Acid Conformation Polyamines Polyamines - chemistry Polydeoxyribonucleotides - chemistry single-molecule studies Stereoisomerism
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Beschreibung
Zusammenfassung:	Normal doughnuts or lots of little ones? Among four stereoisomers of a tetravalent polyamine, the isomer pictured was the most potent at inducing DNA compaction, whereby the DNA molecules adopted a unique morphology of minitoroid clusters. The nonchiral polyamine spermine induced the formation of typical, larger toroidal structures.
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.201209144