Metal-Free Annulation of Arenes with 2-Aminopyridine Derivatives: The Methyl Group as a Traceless Non-Chelating Directing Group
A novel annulation reaction between 2‐aminopyridine derivatives and arenes under metal‐free conditions is described. The presented intermolecular transformation provided straightforward access to the important pyrido[1,2‐a]benzimidazole scaffold under mild reaction conditions. The unprecedented appl...
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Veröffentlicht in: | Angewandte Chemie International Edition 2014-07, Vol.53 (31), p.8163-8166 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | A novel annulation reaction between 2‐aminopyridine derivatives and arenes under metal‐free conditions is described. The presented intermolecular transformation provided straightforward access to the important pyrido[1,2‐a]benzimidazole scaffold under mild reaction conditions. The unprecedented application of the methyl group of methylbenzenes as a traceless, non‐chelating, and highly regioselective directing group is reported.
Disappearing Me: A novel selective annulation between 2‐aminopyridine derivatives and arenes under metal‐free conditions provides the important pyrido[1,2‐a]benzimidazole scaffold under mild reaction conditions. In this intermolecular reaction the methyl group of methylbenzenes serves as a traceless, non‐chelating, and highly regioselective directing group. |
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ISSN: | 1433-7851 1521-3773 |
DOI: | 10.1002/anie.201403712 |