DNA repair proteins

DNA repair proteins

DNA repair proteins act to correct mutagenic and toxic DNA damage, which can lead to cancer, aging and death. These proteins and their mechanisms of action have been found to be widely conserved between species, often from bacteria to man. Structural and biochemical studies on several bacterial enzy...

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Veröffentlicht in:Current opinion in structural biology 1995-02, Vol.5 (1), p.20-26
Hauptverfasser: Tainer, John A., Thayer, Maria M., Cunningham, Richard P.
Format: Artikel
Sprache:eng
Schlagworte:
Amino Acid Sequence
Animals
Bacterial Proteins - chemistry
DNA Repair
Endodeoxyribonucleases - chemistry
Humans
Molecular Sequence Data
Proteins - chemistry
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Zusammenfassung:DNA repair proteins act to correct mutagenic and toxic DNA damage, which can lead to cancer, aging and death. These proteins and their mechanisms of action have been found to be widely conserved between species, often from bacteria to man. Structural and biochemical studies on several bacterial enzymes involved in direct reversal and base excision repair have provided insights into the molecular basis of the recognition of damaged DNA and have also highlighted the novel roles that transition metals play in DNA repair.
ISSN:0959-440X
1879-033X
DOI:10.1016/0959-440X(95)80005-L