Failure of Cefotaxime Treatment in a Patient with Penicillin-Resistant Pneumococcal Meningitis and Confirmation of Nosocomial Spread by Random Amplified Polymorphic DNA Analysis

We report what is to our knowledge the first case of cefotaxime treatment failing in a patient with penicillin-resistant Streptococcus pneumoniae (PRSP) meningitis that was associated with nosocomial spread, as confirmed by DNA fingerprinting with use of randomly amplified polymorphic DNA (RAPD) ana...

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Veröffentlicht in:	Clinical infectious diseases 1995-07, Vol.21 (1), p.234-235
Hauptverfasser:	Raymond, Josette, Bingen, Edouard, Doit, Catherine, Brahimi, Naïma, Bergeret, Michel, Badoual, Jean, Gendrel, Dominique
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics Base Sequence Cefotaxime - therapeutic use Cephalosporins Cephalosporins - therapeutic use Correspondence Cross Infection - diagnosis Cross Infection - microbiology DNA DNA fingerprinting DNA Primers - chemistry DNA, Bacterial - analysis Drug Therapy, Combination - therapeutic use Female Genetic polymorphism Gentamicins - therapeutic use Hospital beds Humans Infant Meningitis, Pneumococcal - diagnosis Meningitis, Pneumococcal - therapy Molecular Sequence Data Pediatrics Penicillin Resistance Pneumococcal meningitis Polymerase chain reaction Polymerase Chain Reaction - methods Polymorphism, Restriction Fragment Length Streptococcus pneumoniae Streptococcus pneumoniae - genetics Treatment Failure Vancomycin - therapeutic use
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Zusammenfassung:	We report what is to our knowledge the first case of cefotaxime treatment failing in a patient with penicillin-resistant Streptococcus pneumoniae (PRSP) meningitis that was associated with nosocomial spread, as confirmed by DNA fingerprinting with use of randomly amplified polymorphic DNA (RAPD) analysis.
ISSN:	1058-4838 1537-6591
DOI:	10.1093/clinids/21.1.234