CSF-1/CSF-1R targeting agents in clinical development for cancer therapy
Highlights • TAM promote tumor growth and efficiently suppress immune effector cells. • Targeting TAM via the CSF-1/CSF-1R pathway is an attractive therapy for cancer. • Can in vitro differentiated macrophages reflect patient-derived TAM? • TAM depletion combined with standard- or immuno-therapies w...
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| Veröffentlicht in: | Current opinion in pharmacology 2015-08, Vol.23, p.45-51 |
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| container_title | Current opinion in pharmacology |
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| creator | Ries, Carola H Hoves, Sabine Cannarile, Michael A Rüttinger, Dominik |
| description | Highlights • TAM promote tumor growth and efficiently suppress immune effector cells. • Targeting TAM via the CSF-1/CSF-1R pathway is an attractive therapy for cancer. • Can in vitro differentiated macrophages reflect patient-derived TAM? • TAM depletion combined with standard- or immuno-therapies will be the way forward. |
| doi_str_mv | 10.1016/j.coph.2015.05.008 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1471-4892 |
| ispartof | Current opinion in pharmacology, 2015-08, Vol.23, p.45-51 |
| issn | 1471-4892 1471-4973 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - immunology Drug Delivery Systems - trends Drug Discovery - trends Humans Internal Medicine Macrophage Colony-Stimulating Factor - immunology Macrophages - drug effects Macrophages - immunology Medical Education Neoplasms - drug therapy Neoplasms - immunology Receptor, Macrophage Colony-Stimulating Factor - immunology Signal Transduction - drug effects Signal Transduction - immunology |
| title | CSF-1/CSF-1R targeting agents in clinical development for cancer therapy |
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