CSF-1/CSF-1R targeting agents in clinical development for cancer therapy

Highlights • TAM promote tumor growth and efficiently suppress immune effector cells. • Targeting TAM via the CSF-1/CSF-1R pathway is an attractive therapy for cancer. • Can in vitro differentiated macrophages reflect patient-derived TAM? • TAM depletion combined with standard- or immuno-therapies w...

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Veröffentlicht in:Current opinion in pharmacology 2015-08, Vol.23, p.45-51
Hauptverfasser: Ries, Carola H, Hoves, Sabine, Cannarile, Michael A, Rüttinger, Dominik
Format: Artikel
Sprache:eng
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Zusammenfassung:Highlights • TAM promote tumor growth and efficiently suppress immune effector cells. • Targeting TAM via the CSF-1/CSF-1R pathway is an attractive therapy for cancer. • Can in vitro differentiated macrophages reflect patient-derived TAM? • TAM depletion combined with standard- or immuno-therapies will be the way forward.
ISSN:1471-4892
1471-4973
DOI:10.1016/j.coph.2015.05.008