CSF-1/CSF-1R targeting agents in clinical development for cancer therapy
Highlights • TAM promote tumor growth and efficiently suppress immune effector cells. • Targeting TAM via the CSF-1/CSF-1R pathway is an attractive therapy for cancer. • Can in vitro differentiated macrophages reflect patient-derived TAM? • TAM depletion combined with standard- or immuno-therapies w...
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Veröffentlicht in: | Current opinion in pharmacology 2015-08, Vol.23, p.45-51 |
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Hauptverfasser: | , , , |
Format: | Artikel |
Sprache: | eng |
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Online-Zugang: | Volltext |
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Zusammenfassung: | Highlights • TAM promote tumor growth and efficiently suppress immune effector cells. • Targeting TAM via the CSF-1/CSF-1R pathway is an attractive therapy for cancer. • Can in vitro differentiated macrophages reflect patient-derived TAM? • TAM depletion combined with standard- or immuno-therapies will be the way forward. |
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ISSN: | 1471-4892 1471-4973 |
DOI: | 10.1016/j.coph.2015.05.008 |