Hypersensitivity Hepatitis due to Pyrazinamide

Pyrazinamide hepatotoxicity is considered secondary to a direct and dose-related toxic effect. At currently used doses, pyrazinamide provides effective short-term treatment and is free from serious side effects. We report a case of pyrazinamide-induced hepatitis for which the rechallenge data strong...

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Veröffentlicht in:	Scandinavian journal of infectious diseases 1995, Vol.27 (1), p.93-94
Hauptverfasser:	Corbella, Xavier, Vadillo, Miquel, Cabellos, Carmen, Fernandezviladrich, Pedro, Rufi, Gabriel
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Biological and medical sciences Chemical and Drug Induced Liver Injury - etiology Chemical and Drug Induced Liver Injury - immunology Dose-Response Relationship, Drug Drug Hypersensitivity Drug toxicity and drugs side effects treatment Female Humans Medical sciences Middle Aged Pharmacology. Drug treatments Pyrazinamide - adverse effects Toxicity: digestive system
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Beschreibung
Zusammenfassung:	Pyrazinamide hepatotoxicity is considered secondary to a direct and dose-related toxic effect. At currently used doses, pyrazinamide provides effective short-term treatment and is free from serious side effects. We report a case of pyrazinamide-induced hepatitis for which the rechallenge data strongly suggest a hypersensitivity mechanism.
ISSN:	0036-5548 1651-1980
DOI:	10.3109/00365549509018984