Asteltoxins from the Entomopathogenic Fungus Pochonia bulbillosa 8‑H-28

New asteltoxins C (3) and D (4) were found in the extract of the entomopathogenic fungus Pochonia bulbillosa 8-H-28. Compound 2, which was spectroscopically identical with the known asteltoxin B, was isolated, and structural analysis led to a revision of the structure of asteltoxin B. Compounds 2 an...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2015-07, Vol.78 (7), p.1730-1734
Hauptverfasser:	Adachi, Hayamitsu, Doi, Hiroyasu, Kasahara, Yuichi, Sawa, Ryuichi, Nakajima, Kaori, Kubota, Yumiko, Hosokawa, Nobuo, Tateishi, Ken, Nomoto, Akio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Survival - drug effects Depsipeptides - pharmacology Hypocreales - chemistry Japan Larva - drug effects Molecular Structure Nuclear Magnetic Resonance, Biomolecular Pyrones - chemistry Pyrones - isolation & purification Pyrones - pharmacology Spodoptera - drug effects
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Beschreibung
Zusammenfassung:	New asteltoxins C (3) and D (4) were found in the extract of the entomopathogenic fungus Pochonia bulbillosa 8-H-28. Compound 2, which was spectroscopically identical with the known asteltoxin B, was isolated, and structural analysis led to a revision of the structure of asteltoxin B. Compounds 2 and 4 have a novel tricyclic ring system connected to a dienyl α-pyrone structure. Compound 3 has a 2,8-dioxabicyclo[3.3.0]octane ring similar to that of asteltoxin (1). Compound 3 showed potent antiproliferative activity against NIAS-SL64 cells derived from the fat body of Spodoptera litura larvae, while 2 and 4 were inactive.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np500676j