Rating scales to measure side effects of antipsychotic medication: A systematic review

Introduction: Many patients experience side effects during treatment with antipsychotics. This article reviews the clinical use and psychometric characteristics of rating scales used to assess side effects in patients treated with antipsychotics. Methods: A systematic literature search was performed using the electronic databases PubMed and Embase, with predefined search terms. Results: In total, 52 different scales were used in the 440 articles retrieved. For multiple side effects measured with one scale, the Udvalg for Kliniske Undersøgelser Side Effects Rating Scale for Clinicians was used the most, whereas the Liverpool University Neuroleptic Side Effect Rating Scale had the best psychometric characteristics (Cronbach’s α 0.81 and test–retest reliability 0.89). The Simpson Angus Scale was used the most to rate extrapyramidal side effects, although the Maryland Psychiatric Research Center scale had the best characteristics (Cronbach’s α 0.80, test–retest reliability 0.92 and inter-rater reliability 0.81–0.90). The Arizona Sexual Experience Scale was used the most to assess sexual dysfunction, but the Antipsychotics and Sexual Functioning Questionnaire and the Nagoya Sexual Functioning Questionnaire had the best characteristics. Conclusion: This review will help researchers and clinicians make a purpose-oriented choice of which scale to use. Systematic review registration number: CRD42014013010.