Synthesis of Resveratrol Glycosides by Plant Glucosyltransferase and Cyclodextrin Glucanotransferase and Their Neuroprotective Activity

Resveratrol was converted by glucosyltransferase from Phytolacca americana into its 3- and 4′-O-β-D-glucosides. On the other hand, further glycosylation of resveratrol 4′-O-β-D-glucoside by cyclodextrin glucanotransferase gave the 4′-O-β-maltoside, 4′-O-β-maltotrioside, 4′-O-β-maltotetraoside, and 4′-O-β-maltopentaoside of resveratrol. The six resveratrol glycosides synthesized here showed higher phosphodiesterase inhibitory activity than resveratrol.