Effect of plasmids harbouring blaCTX-M on the virulence and fitness of Escherichia coli ST131 isolates

Highlights • We investigated the effect of plasmids harbouring blaCTX-M on the virulence and fitness on Escherichia coli ST131 isolates. • Non-ESBL-producing E. coli ST131 isolates were more competitive and virulent than CTX-M-producing E. coli ST131 isolates. • Transconjugants harbouring blaCTX-M w...

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Veröffentlicht in:	International journal of antimicrobial agents 2015-08, Vol.46 (2), p.214-218
Hauptverfasser:	Shin, Juyoun, Ko, Kwan Soo
Format:	Artikel
Sprache:	eng
Schlagworte:	beta-Lactamases - genetics beta-Lactamases - secretion Biofilms - growth & development Blood Bactericidal Activity Conjugation, Genetic CTX-M-14 CTX-M-15 Escherichia coli - classification Escherichia coli - enzymology Escherichia coli - genetics Escherichia coli - physiology Escherichia coli Infections - microbiology Humans Infectious Disease Plasmid Plasmids Sequence type 131 ST131 Transformation, Bacterial Virulence
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Beschreibung
Zusammenfassung:	Highlights • We investigated the effect of plasmids harbouring blaCTX-M on the virulence and fitness on Escherichia coli ST131 isolates. • Non-ESBL-producing E. coli ST131 isolates were more competitive and virulent than CTX-M-producing E. coli ST131 isolates. • Transconjugants harbouring blaCTX-M were no less competitive than their susceptible hosts.
ISSN:	0924-8579 1872-7913
DOI:	10.1016/j.ijantimicag.2015.04.012