Molecular identification of aminoglycoside-modifying enzymes in clinical isolates of Escherichia coli resistant to amoxicillin/clavulanic acid isolated in Spain

Highlights • A remarkable diversity of aminoglycoside-resistant Escherichia coli was found. • Fifteen aminoglycoside-modifying enzyme (AME) patterns showed different levels of aminoglycoside resistance. • aac(6 ′ )-Ib was the most prevalent AME gene and was associated with CTX-M-15. • The ant(2 ″ )-...

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Veröffentlicht in:	International journal of antimicrobial agents 2015-08, Vol.46 (2), p.157-163
Hauptverfasser:	Fernández-Martínez, Marta, Miró, Elisenda, Ortega, Adriana, Bou, Germán, González-López, Juan José, Oliver, Antonio, Pascual, Alvaro, Cercenado, Emilia, Oteo, Jesús, Martínez-Martínez, Luis, Navarro, Ferran
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetyltransferases - genetics Aminoglycoside Aminoglycoside-modifying enzyme Aminoglycosides - metabolism Amoxicillin - metabolism Amoxicillin/clavulanic acid Anti-Bacterial Agents - metabolism Clavulanic Acid - metabolism Cluster Analysis Drug Resistance, Bacterial Escherichia coli Escherichia coli - enzymology Escherichia coli - genetics Escherichia coli - isolation & purification Escherichia coli Infections - microbiology Humans Inactivation, Metabolic Infectious Disease Kanamycin Kinase - genetics Microbial Sensitivity Tests Molecular Sequence Data Nucleotidyltransferases - genetics Resistance RNA, Ribosomal, 16S - metabolism Spain tRNA Methyltransferases - genetics
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Zusammenfassung:	Highlights • A remarkable diversity of aminoglycoside-resistant Escherichia coli was found. • Fifteen aminoglycoside-modifying enzyme (AME) patterns showed different levels of aminoglycoside resistance. • aac(6 ′ )-Ib was the most prevalent AME gene and was associated with CTX-M-15. • The ant(2 ″ )-Ia gene was usually associated with OXA-1. • The expected phenotypes and genotypes did not match in 35.4% of isolates.
ISSN:	0924-8579 1872-7913
DOI:	10.1016/j.ijantimicag.2015.03.008