Ectosomes and exosomes: shedding the confusion between extracellular vesicles

Highlights • The characteristics and mechanisms of ectosomes and exosomes are defined. • Exosomes are released on the exocytosis of MVBs, whereas ectosomes are assembled and released from the plasma membrane. • Interactions of vesicles with target cells and vesicle navigation are illustrated. • The...

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Veröffentlicht in:	Trends in cell biology 2015-06, Vol.25 (6), p.364-372
Hauptverfasser:	Cocucci, Emanuele, Meldolesi, Jacopo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals cancer diagnosis and therapy Cell Communication - physiology cell targets Cell-Derived Microparticles - metabolism endocytosis ESCRT Exocytosis - physiology Exosomes - metabolism extracellular vesicles Humans membrane fusions mediated by fusogens multivesicular bodies Multivesicular Bodies - metabolism Pathology vesicle assembly vesicle pinching off and release
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Beschreibung
Zusammenfassung:	Highlights • The characteristics and mechanisms of ectosomes and exosomes are defined. • Exosomes are released on the exocytosis of MVBs, whereas ectosomes are assembled and released from the plasma membrane. • Interactions of vesicles with target cells and vesicle navigation are illustrated. • The role of vesicles in cancer diagnosis and therapy is discussed.
ISSN:	0962-8924 1879-3088
DOI:	10.1016/j.tcb.2015.01.004