Selective contributions of neuronal and astroglial interleukin-1 receptor 1 to the regulation of sleep
Highlights • Transgenic mice were used to study cell-specific contributions of IL1R1 to sleep. • Transgenic IL1R1 mice have more REMS and enhanced NREMS delta power. • Astroglial IL1R1 modulates homeostatic sleep responses to sleep deprivation. • Selective IL1R1 expression on astrocytes or on neuron...
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| Veröffentlicht in: | Brain, behavior, and immunity behavior, and immunity, 2015-08, Vol.48, p.244-257 |
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| container_title | Brain, behavior, and immunity |
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| creator | Ingiosi, Ashley M Raymond, Richard M Pavlova, Maria N Opp, Mark R |
| description | Highlights • Transgenic mice were used to study cell-specific contributions of IL1R1 to sleep. • Transgenic IL1R1 mice have more REMS and enhanced NREMS delta power. • Astroglial IL1R1 modulates homeostatic sleep responses to sleep deprivation. • Selective IL1R1 expression on astrocytes or on neurons is not sufficient for IL-1 to induce sleep. • IL1R1 expression on neurons and astrocytes and/or some upstream cellular substrate may be required for IL-1 to induce sleep. |
| doi_str_mv | 10.1016/j.bbi.2015.03.014 |
| format | Article |
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| ispartof | Brain, behavior, and immunity, 2015-08, Vol.48, p.244-257 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Allergy and Immunology Animals Astrocyte Astrocytes - drug effects Astrocytes - physiology Body Temperature - drug effects Body Temperature - physiology Cytokine Electroencephalography Fever IL-1 IL-6 Interleukin-1 - pharmacology Male Mice Mice, Transgenic Neuron Neurons - drug effects Neurons - physiology Psychiatry Receptors, Interleukin-1 - genetics Receptors, Interleukin-1 - metabolism Sleep Sleep - drug effects Sleep - physiology |
| title | Selective contributions of neuronal and astroglial interleukin-1 receptor 1 to the regulation of sleep |
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