Selective contributions of neuronal and astroglial interleukin-1 receptor 1 to the regulation of sleep

Highlights • Transgenic mice were used to study cell-specific contributions of IL1R1 to sleep. • Transgenic IL1R1 mice have more REMS and enhanced NREMS delta power. • Astroglial IL1R1 modulates homeostatic sleep responses to sleep deprivation. • Selective IL1R1 expression on astrocytes or on neurons is not sufficient for IL-1 to induce sleep. • IL1R1 expression on neurons and astrocytes and/or some upstream cellular substrate may be required for IL-1 to induce sleep.