Fatal Group A Streptococcal Meningitis and Toxic Shock-Like Syndrome: Case Report

A previously healthy 8-year-old girl presented with flulike symptoms, developed toxic shock-like syndrome, and died within 48 hours. At autopsy she was found to have purulent meningitis. The group A β-hemolytic streptococcus isolated from her CSF was a member of clone ET 2. This strain produced a va...

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Veröffentlicht in:	Clinical infectious diseases 1994-01, Vol.18 (1), p.91-93
Hauptverfasser:	Jevon, Gareth P., Dunne, W. Michael, Hawkins, Hal K., Armstrong, Dawna L., Musser, James M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial diseases Biological and medical sciences Brain - microbiology Brain - pathology Chickenpox Child Exanthema Exotoxins Fatal Outcome Female Gram positive cocci Human bacterial diseases Humans Infections Infectious diseases Medical sciences Meningitis Meningitis, Bacterial - cerebrospinal fluid Meningitis, Bacterial - microbiology Meningitis, Bacterial - pathology Nervous system diseases Pathology Shock, Septic - cerebrospinal fluid Shock, Septic - microbiology Staphylococcal infections, streptococcal infections, pneumococcal infections Streptococcal Infections - cerebrospinal fluid Streptococcal Infections - pathology Streptococcus pyogenes Toxicity
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Zusammenfassung:	A previously healthy 8-year-old girl presented with flulike symptoms, developed toxic shock-like syndrome, and died within 48 hours. At autopsy she was found to have purulent meningitis. The group A β-hemolytic streptococcus isolated from her CSF was a member of clone ET 2. This strain produced a variant form of streptococcal pyrogenic exotoxin A (SPEA2) that has recently been associated with widespread toxic shock-like syndrome.
ISSN:	1058-4838 1537-6591
DOI:	10.1093/clinids/18.1.91