Two Ene–Yne Metathesis Approaches to the Total Synthesis of Amphidinolide P

The total synthesis of amphidinolide P was achieved through two different ene–yne metathesis approaches. In each approach, the metathesis step was performed at late stages in the synthesis with all other functionality present. By forging two successful pathways to the synthesis of 1, some of the strengths and weaknesses of metathesis-intensive synthetic strategies were identified.