Age and comorbidities deeply impact on clinical outcome of patients with myelodysplastic syndromes

Highlights • We examine the effects of age and comorbidity in a real-life series of MDS patients. • Both age and comorbidities exert a significant, independent impact on clinical outcome. • The role of comorbidity in predicting outcome is best described by the MDS-CI score system. • The impact of MD...

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Veröffentlicht in:	Leukemia research 2015-08, Vol.39 (8), p.846-852
Hauptverfasser:	Balleari, E, Salvetti, C, Del Corso, L, Filiberti, R, Bacigalupo, A, Bellodi, A, Beltrami, G, Bergamaschi, M, Berisso, G, Calzamiglia, T, Carella, A.M, Cavalleri, M, Da Col, A, Favorini, S, Forni, G.L, Goretti, R, Miglino, M, Mitscheuning, L, Molinari, E, Racchi, O, Scudeletti, M, Tassara, R, Gobbi, M, Lemoli, R, Clavio, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Factors Aged Aged, 80 and over Comorbidity Elderly Female Hematology, Oncology and Palliative Medicine Humans Male Middle Aged Myelodysplastic syndromes Myelodysplastic Syndromes - diagnosis Myelodysplastic Syndromes - epidemiology Myelodysplastic Syndromes - mortality Prevalence Prognosis Retrospective Studies Survival Analysis
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Zusammenfassung:	Highlights • We examine the effects of age and comorbidity in a real-life series of MDS patients. • Both age and comorbidities exert a significant, independent impact on clinical outcome. • The role of comorbidity in predicting outcome is best described by the MDS-CI score system. • The impact of MDS-CI on outcome has particular relevance in lower-risk MDS patients.
ISSN:	0145-2126 1873-5835
DOI:	10.1016/j.leukres.2015.05.007