Regioselective Cross-Couplings of Coumarins and Flavones with Ethers via C(sp3)–H Functionalization

Regioselective Cross-Couplings of Coumarins and Flavones with Ethers via C(sp3)–H Functionalization

Coumarin and flavone derivatives are highly valuable molecules in drug discovery. Here, two new regioselective cross-dehydrogenation couplings of coumarins and flavones with different ethers via C­(sp3)–H functionalization processes were developed, generating new ether-substituted derivatives not pr...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of organic chemistry 2015-07, Vol.80 (14), p.7251-7257
Hauptverfasser: Niu, Ben, Zhao, Wannian, Ding, Yingcai, Bian, Zhaogang, Pittman, Charles U, Zhou, Aihua, Ge, Haibo
Format: Artikel
Sprache:eng
Schlagworte:
Catalysis
Coumarins - chemistry
Drug Discovery
Ethers - chemical synthesis
Ethers - chemistry
Flavones - chemistry
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Coumarin and flavone derivatives are highly valuable molecules in drug discovery. Here, two new regioselective cross-dehydrogenation couplings of coumarins and flavones with different ethers via C­(sp3)–H functionalization processes were developed, generating new ether-substituted derivatives not previously reported. These reactions proceeded well via radical mechanisms and provided the corresponding products in good yields.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.5b00800