Total Synthesis of Shishijimicin A

Total Synthesis of Shishijimicin A

The total synthesis of the rare but extremely potent antitumor agent shishijimicin A has been achieved via a convergent strategy involving carboline disaccharide 3 and hydroxy enediyne thioacetate 4.

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Veröffentlicht in:Journal of the American Chemical Society 2015-07, Vol.137 (27), p.8716-8719
Hauptverfasser: Nicolaou, K. C, Lu, Zhaoyong, Li, Ruofan, Woods, James R, Sohn, Te-ik
Format: Artikel
Sprache:eng
Schlagworte:
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - chemistry
Biological Products - chemical synthesis
Biological Products - chemistry
Carbolines - chemical synthesis
Carbolines - chemistry
Disaccharides - chemical synthesis
Disaccharides - chemistry
Enediynes - chemical synthesis
Enediynes - chemistry
Sulfhydryl Compounds - chemical synthesis
Sulfhydryl Compounds - chemistry
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Beschreibung
Zusammenfassung:The total synthesis of the rare but extremely potent antitumor agent shishijimicin A has been achieved via a convergent strategy involving carboline disaccharide 3 and hydroxy enediyne thioacetate 4.
ISSN:0002-7863
1520-5126
DOI:10.1021/jacs.5b05575