Continuous cell subline A4C2/9K and its application to the african swine fever virus study

A new continuous cell subline A4C2/9K highly sensitive to the african swine fever virus (ASFV) was prepared. All the tested ASFV strains isolated in the Russian Federation in 2008-2013 proliferated in this cell culture exhibiting hemadsorption and accumulated at a titer of up to 6.5 Ig HAU50/cm3. Th...

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Veröffentlicht in:	Voprosy virusologiĭ 2015, Vol.60 (2), p.43-47
Hauptverfasser:	Balysheva, V I, Prudnikova, E Yu, Galnbek, T V, Balyshev, V M
Format:	Artikel
Sprache:	rus
Schlagworte:	African Swine Fever - immunology African Swine Fever Virus - growth & development African Swine Fever Virus - immunology African Swine Fever Virus - pathogenicity Animals Cell Line - cytology Cell Line - virology Russia Swine
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Zusammenfassung:	A new continuous cell subline A4C2/9K highly sensitive to the african swine fever virus (ASFV) was prepared. All the tested ASFV strains isolated in the Russian Federation in 2008-2013 proliferated in this cell culture exhibiting hemadsorption and accumulated at a titer of up to 6.5 Ig HAU50/cm3. The cell culture A4C2/9K can be used for ASFV isolation or determination of its infectious activity and serotype identity. The culture versions of the ASFV strain Stavropol 01/08 at passages 24 and 33 in the cell culture A4C2/9K lost their pathogenicity for pigs.
ISSN:	0507-4088