Gualamycin, a Novel Acaricide Produced by Streptomyces sp. NK11687: II. Structural Elucidation

A novel acaricide, gualamycin was isolated from the culture broth of Streptomyces sp. NK11687. The structure of gualamycin was determined to be (2R, 3S, 4S)-2-O-[4-O-(2-amino-2-deoxy-β-D-gulopyranosyl)-a-D-galactopyranosyl]-2, 3, 4-trihydroxy-4-[(2S, 3S, 4S, 5S)-3, 4-dihydroxy-5-hydroxymethylpyrroli...

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Veröffentlicht in:	Journal of antibiotics 1995/07/25, Vol.48(7), pp.630-634
Hauptverfasser:	TSUCHIYA, KOUICHI, KOBAYASHI, SFFINICHI, KUROKAWA, TAKASHI, NAKAGAWA, TAIZO, SHIMADA, NOBUYOSHI, NAKAMURA, HIKARU, IITAKA, YOICHI, KITAGAWA, MASAYUKI, TATSUTA, KUNIAKI
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics. Antiinfectious agents. Antiparasitic agents Antiparasitic agents Biological and medical sciences Disaccharides - chemistry Disaccharides - isolation & purification Insecticides - chemistry Insecticides - isolation & purification Magnetic Resonance Spectroscopy Medical sciences Molecular Structure Pharmacology. Drug treatments Pyrrolidines - chemistry Pyrrolidines - isolation & purification Streptomyces
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Zusammenfassung:	A novel acaricide, gualamycin was isolated from the culture broth of Streptomyces sp. NK11687. The structure of gualamycin was determined to be (2R, 3S, 4S)-2-O-[4-O-(2-amino-2-deoxy-β-D-gulopyranosyl)-a-D-galactopyranosyl]-2, 3, 4-trihydroxy-4-[(2S, 3S, 4S, 5S)-3, 4-dihydroxy-5-hydroxymethylpyrrolidin-2-yl] butanoic acid by FAB-MS, 1H and 13C NMR, COSY, HMQC, HMBC, IR, X-ray crystallographic analyses and synthetic studies.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.48.630