In vitro Evaluation of the Anti-Picornavirus Activities of New Synthetic Flavonoids
Substituted oxazolinylflavons and oxazolinylflavanones were synthesized in order to compare their anti-picornavirus activities with those of related natural and synthetic compounds. The antiviral potencies of the new compounds were evaluated against rhino-virus type 1B and poliovirus type 2 by a pla...
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Veröffentlicht in: | Antiviral chemistry & chemotherapy 1995-10, Vol.6 (5), p.298-306 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Substituted oxazolinylflavons and oxazolinylflavanones were synthesized in order to compare their anti-picornavirus activities with those of related natural and synthetic compounds. The antiviral potencies of the new compounds were evaluated against rhino-virus type 1B and poliovirus type 2 by a plaque reduction assay in HeLa cell cultures. Among the substituted flavanones only 6-chloro-4′-oxazolinylflavanone showed activity against both viruses. A comparison of the effects of 3-substituted flavones indicated that the presence of a 3-methoxy group enhances the activity against rhinovirus, while the presence of a 3-hydroxy group enhances the activity against poliovirus. |
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ISSN: | 2040-2066 0956-3202 2040-2066 |
DOI: | 10.1177/095632029500600503 |