Enhancement of rag1 and tdt expression in thymus after immunization

The aim of this work was to assess the level of expression of rag1 and tdt genes in mouse thymic cells in response to immunization. In general, it can be concluded that T cell progen itors respond to xenoantigen administration by increasing the expression of rag1 and tdt genes and that preliminary s...

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Veröffentlicht in:	Doklady. Biochemistry and biophysics 2015-05, Vol.462 (1), p.196-198
Hauptverfasser:	Vassiliev, K. A., Polevshchikov, A. V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens Biochemistry Biological and Medical Physics Biomedical and Life Sciences Biophysics Biophysics and Molecular Biology DNA Nucleotidylexotransferase - genetics Female Gene Expression Regulation - immunology Homeodomain Proteins - genetics Immune system Immunization Life Sciences Mice T cell receptors
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Zusammenfassung:	The aim of this work was to assess the level of expression of rag1 and tdt genes in mouse thymic cells in response to immunization. In general, it can be concluded that T cell progen itors respond to xenoantigen administration by increasing the expression of rag1 and tdt genes and that preliminary stimulation of phagocytes accelerates this process. Possibly, these results may lead to a significant correction of the notion of the process of maturation and differentiation of T cells and immunophysiology of the thymus in general.
ISSN:	1607-6729 1608-3091
DOI:	10.1134/S1607672915030151