Levosimendan Improves Hemodynamic Status in Critically Ill Patients with Severe Aortic Stenosis and Left Ventricular Dysfunction: An Interventional Study

Levosimendan Improves Hemodynamic Status in Critically Ill Patients with Severe Aortic Stenosis and Left Ventricular Dysfunction: An Interventional Study

Summary Aims To study the hemodynamic effect of levosimendan administration in acute heart failure patients with severe aortic stenosis (AS) and reduced left ventricular ejection fraction (LVEF). Methods Hemodynamic response to 24 h intravenous levosimendan infusion (0.1 μg/kg/min without a loading...

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Veröffentlicht in:Cardiovascular therapeutics 2015-08, Vol.33 (4), p.193-199
Hauptverfasser: García‐González, Martín J., Jorge‐Pérez, Pablo, Jiménez‐Sosa, Alejandro, Acea, Antonio Barragán, Lacalzada Almeida, Juan B., Ferrer Hita, Julio J.
Format: Artikel
Sprache:eng
Schlagworte:
Acute heart failure
Aged
Aged, 80 and over
Aortic stenosis
Aortic Valve Stenosis - diagnosis
Aortic Valve Stenosis - drug therapy
Aortic Valve Stenosis - physiopathology
Cardiology
Cardiovascular Agents - administration & dosage
Cardiovascular Agents - adverse effects
Cardiovascular Agents - therapeutic use
Critical cardiac care
Critical Illness
Female
Heart Failure - diagnosis
Heart Failure - physiopathology
Heart Failure - therapy
Hemodynamics - drug effects
Humans
Hydrazones - administration & dosage
Hydrazones - adverse effects
Hydrazones - therapeutic use
Infusions, Intravenous
Left ventricular dysfunction
Levosimendan
Male
Middle Aged
Pulmonary arteries
Pyridazines - administration & dosage
Pyridazines - adverse effects
Pyridazines - therapeutic use
Recovery of Function
Severity of Illness Index
Spain
Stroke Volume - drug effects
Time Factors
Treatment Outcome
Ventricular Dysfunction, Left - diagnosis
Ventricular Dysfunction, Left - physiopathology
Ventricular Dysfunction, Left - therapy
Ventricular Function, Left - drug effects
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Zusammenfassung:Summary Aims To study the hemodynamic effect of levosimendan administration in acute heart failure patients with severe aortic stenosis (AS) and reduced left ventricular ejection fraction (LVEF). Methods Hemodynamic response to 24 h intravenous levosimendan infusion (0.1 μg/kg/min without a loading dose) in patients with severe AS (aortic valve area ≤1 cm2, time‐velocity integral between left ventricular out‐flow tract and aortic valve
ISSN:1755-5914
1755-5922
DOI:10.1111/1755-5922.12132