The microbiological diagnosis of tuberculous meningitis: results of Haydarpasa‐1 study

We aimed to provide data on the diagnosis of tuberculous meningitis (TBM) in this largest case series ever reported. The Haydarpasa‐1 study involved patients with microbiologically confirmed TBM in Albania, Croatia, Denmark, Egypt, France, Hungary, Iraq, Italy, Macedonia, Romania, Serbia, Slovenia,...

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Veröffentlicht in:	Clinical microbiology and infection 2014-10, Vol.20 (10), p.O600-O608
Hauptverfasser:	Erdem, H., Ozturk‐Engin, D., Elaldi, N., Gulsun, S., Sengoz, G., Crisan, A., Johansen, I. S., Inan, A., Nechifor, M., Al‐Mahdawi, A., Civljak, R., Ozguler, M., Savic, B., Ceran, N., Cacopardo, B., Inal, A. S., Namiduru, M., Dayan, S., Kayabas, U., Parlak, E., Khalifa, A., Kursun, E., Sipahi, O. R., Yemisen, M., Akbulut, A., Bitirgen, M., Dulovic, O., Kandemir, B., Luca, C., Parlak, M., Stahl, J. P., Pehlivanoglu, F., Simeon, S., Ulu‐Kilic, A., Yasar, K., Yilmaz, G., Yilmaz, E., Beovic, B., Catroux, M., Lakatos, B., Sunbul, M., Oncul, O., Alabay, S., Sahin‐Horasan, E., Kose, S., Shehata, G., Andre, K., Alp, A., Ćosić, G., Cem Gul, H., Karakas, A., Chadapaud, S., Hansmann, Y., Harxhi, A., Kirova, V., Masse‐Chabredier, I., Oncu, S., Sener, A., Tekin, R., Deveci, O., Karabay, O., Agalar, C., Allerberger, F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Deaminase - cerebrospinal fluid Adolescent Adult Aged Aged, 80 and over Bacteriological Techniques - methods culture diagnosis Early Diagnosis Female Humans Interferon-gamma Release Tests - methods Male meningitis Middle Aged Mycobacterium tuberculosis - isolation & purification PCR Precision Medicine Retrospective Studies tuberculosis Tuberculosis, Meningeal - cerebrospinal fluid Tuberculosis, Meningeal - diagnosis Tuberculosis, Meningeal - microbiology Young Adult
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Zusammenfassung:	We aimed to provide data on the diagnosis of tuberculous meningitis (TBM) in this largest case series ever reported. The Haydarpasa‐1 study involved patients with microbiologically confirmed TBM in Albania, Croatia, Denmark, Egypt, France, Hungary, Iraq, Italy, Macedonia, Romania, Serbia, Slovenia, Syria and Turkey between 2000 and 2012. A positive culture, PCR or Ehrlich–Ziehl–Neelsen staining (EZNs) from the cerebrospinal fluid (CSF) was mandatory for inclusion of meningitis patients. A total of 506 TBM patients were included. The sensitivities of the tests were as follows: interferon‐γ release assay (Quantiferon TB gold in tube) 90.2%, automated culture systems (ACS) 81.8%, Löwenstein Jensen medium (L‐J) 72.7%, adenosine deaminase (ADA) 29.9% and EZNs 27.3%. CSF‐ACS was superior to CSF L‐J culture and CSF‐PCR (p
ISSN:	1198-743X 1469-0691
DOI:	10.1111/1469-0691.12478