The dopamine transporter gene may not contribute to susceptibility and the specific personality traits of amphetamine dependence

Highlights • DAT1 gene was analyzed in patients with amphetamine dependence (AD), and different personality. • A weak association was found between the rs27072 polymorphism and development of AD. • The borderline associations were not evident in subsequent correction. • High harm avoidance and novel...

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Veröffentlicht in:	Drug and alcohol dependence 2015-04, Vol.149, p.100-107
Hauptverfasser:	Tzeng, Nian-Sheng, Lu, Ru-Band, Yeh, Hui-Wen, Yeh, Yi-Wei, Huang, Chang-Chih, Yen, Che-Hung, Kuo, Shin-Chang, Chen, Chun-Yen, Chang, Hsin-An, Ho, Pei-Shen, Cheng, Serena, Shih, Mei-Chen, Huang, San-Yuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Amphetamine dependence Amphetamine-Related Disorders - genetics Amphetamine-Related Disorders - psychology Asian Continental Ancestry Group Case-Control Studies Chinese men DAT1 gene Diagnostic and Statistical Manual of Mental Disorders Dopamine Plasma Membrane Transport Proteins - genetics Exploratory Behavior Genetic Variation Genotype Haplotypes Humans Male Middle Aged Personality - genetics Personality Tests Personality trait Polymorphism, Single Nucleotide Psychiatry
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Zusammenfassung:	Highlights • DAT1 gene was analyzed in patients with amphetamine dependence (AD), and different personality. • A weak association was found between the rs27072 polymorphism and development of AD. • The borderline associations were not evident in subsequent correction. • High harm avoidance and novelty seeking personality may be a risk factor for the development of AD. • DAT1 gene may not contribute to AD susceptibility and specific personality traits.
ISSN:	0376-8716 1879-0046
DOI:	10.1016/j.drugalcdep.2015.01.030