Confocal scanning laser tomography of the optic nerve head on the patients with Alzheimer’s disease compared to glaucoma and control

The purpose of this study was to evaluate optic nerve head (ONH) differences of the patients with Alzheimer’s disease (AD) measured by confocal scanning laser tomography [Heidelberg Retina Tomograph (HRT) III] and compare with glaucoma and control subjects. Eighty-four patients were enrolled into th...

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Veröffentlicht in:International ophthalmology 2014-12, Vol.34 (6), p.1203-1211
Hauptverfasser: Kurna, Sevda Aydin, Akar, Gokcen, Altun, Ahmet, Agirman, Yasemin, Gozke, Eren, Sengor, Tomris
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Sprache:eng
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Zusammenfassung:The purpose of this study was to evaluate optic nerve head (ONH) differences of the patients with Alzheimer’s disease (AD) measured by confocal scanning laser tomography [Heidelberg Retina Tomograph (HRT) III] and compare with glaucoma and control subjects. Eighty-four patients were enrolled into the study: 44 eyes of 24 patients with mild to moderate AD (Group 1), 68 eyes of 35 patients with glaucoma (Group 2), and 49 eyes of 25 heathy volunteers as a control (Group 3). A complete ophthalmologic examination as well as a confocal scanning laser ophthalmoscopic assessment with HRT III were performed on all patients. Mean values of the ONH topographic parameters such as rim area (RA), rim volume (RV), height variation contour, linear cup/disc ratio, cup shape measure, and retinal nerve fiber layer (RNFL) were recorded. Mean values of RNFL thickness was 0.23 ± 0.07 in AD, 0.22 ± 0.09 in glaucoma and 0.24 ± 0.07 in the control group ( p  = 0.323). RA and RV were significantly lower, and linear C/D ratio was significantly higher in the glaucoma group when compared to AD and control ( p   0.05). We observed a negative correlation of the age with RNFL in all of the groups ( p  
ISSN:0165-5701
1573-2630
DOI:10.1007/s10792-014-0004-z