Synthesis and antimicrobial activity of 6-aryl-3,4-dimethyl-N-phenyl-2-oxo-1,2,3,6-tetrahydropyrimidine-5- c arboxamides

Synthesis and antimicrobial activity of 6-aryl-3,4-dimethyl-N-phenyl-2-oxo-1,2,3,6-tetrahydropyrimidine-5- c arboxamides

Three-component reaction of acetoacetanilide, aromatic aldehydes, and N-methylurea afforded 6-aryl-3,4-dimethyl-N-phenyl-2-oxo-1,2,3,6-tetrahydropyrimidine-5- c arboxamides. IR, super(1)H NMR spectroscopy, mass spectrometry, and X-ray diffraction analysis data confirmed the structure of the compound...

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Veröffentlicht in:Russian journal of general chemistry 2014-10, Vol.84 (10), p.1950-1952
Hauptverfasser: Zamaraeva, T M, Odegova, T F, Fedotov, AYu, Tomilov, M V, Gein, V L, Slepukhin, P A
Format: Artikel
Sprache:eng
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Zusammenfassung:Three-component reaction of acetoacetanilide, aromatic aldehydes, and N-methylurea afforded 6-aryl-3,4-dimethyl-N-phenyl-2-oxo-1,2,3,6-tetrahydropyrimidine-5- c arboxamides. IR, super(1)H NMR spectroscopy, mass spectrometry, and X-ray diffraction analysis data confirmed the structure of the compounds obtained. Antimicrobial activity of these compounds was investigated.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363214100168