Synthesis of a novel series of fluoroarene derivatives of artemisinin as potent antifungal and anticancer agent
[Display omitted] A series of new fluoroarene derivatives of artemisinin were prepared using Suzuki and Sonogashira cross-coupling reactions. An antifungal and antitumor activity was evaluated against opportunistic pathogen Fusarium oxysporum and Hela cancer cell line. All these derivatives have sho...
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| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2015-08, Vol.25 (16), p.3338-3341 |
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| container_end_page | 3341 |
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| container_issue | 16 |
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| container_title | Bioorganic & medicinal chemistry letters |
| container_volume | 25 |
| creator | Buragohain, Pori Surineni, Naresh Barua, Nabin C. Bhuyan, Purnajyoti D. Boruah, Paran Borah, Jagat C. Laisharm, Surbala Moirangthem, Dinesh Singh |
| description | [Display omitted]
A series of new fluoroarene derivatives of artemisinin were prepared using Suzuki and Sonogashira cross-coupling reactions. An antifungal and antitumor activity was evaluated against opportunistic pathogen Fusarium oxysporum and Hela cancer cell line. All these derivatives have shown moderate to good activity. |
| doi_str_mv | 10.1016/j.bmcl.2015.05.067 |
| format | Article |
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A series of new fluoroarene derivatives of artemisinin were prepared using Suzuki and Sonogashira cross-coupling reactions. An antifungal and antitumor activity was evaluated against opportunistic pathogen Fusarium oxysporum and Hela cancer cell line. All these derivatives have shown moderate to good activity.</description><identifier>ISSN: 0960-894X</identifier><identifier>EISSN: 1464-3405</identifier><identifier>DOI: 10.1016/j.bmcl.2015.05.067</identifier><identifier>PMID: 26099535</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Anticancer ; Antifungal ; Antifungal Agents - chemical synthesis ; Antifungal Agents - chemistry ; Antifungal Agents - pharmacology ; Antineoplastic Agents - chemical synthesis ; Antineoplastic Agents - chemistry ; Antineoplastic Agents - pharmacology ; Artemisinin ; Artemisinins - chemistry ; Artemisinins - pharmacology ; Cell Proliferation - drug effects ; Cell Survival - drug effects ; Fluorobenzenes - chemistry ; Fluorobenzenes - pharmacology ; Fusarium - drug effects ; Fusarium oxysporum ; HeLa Cells ; Humans ; Microbial Sensitivity Tests ; Structure-Activity Relationship ; Suzuki cross-coupling</subject><ispartof>Bioorganic & medicinal chemistry letters, 2015-08, Vol.25 (16), p.3338-3341</ispartof><rights>2015 Elsevier Ltd</rights><rights>Copyright © 2015 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c426t-33d687aee6360c62e9333e544a42506a57022495a84b71f768ab28d5a233cbd73</citedby><cites>FETCH-LOGICAL-c426t-33d687aee6360c62e9333e544a42506a57022495a84b71f768ab28d5a233cbd73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0960894X15005417$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26099535$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Buragohain, Pori</creatorcontrib><creatorcontrib>Surineni, Naresh</creatorcontrib><creatorcontrib>Barua, Nabin C.</creatorcontrib><creatorcontrib>Bhuyan, Purnajyoti D.</creatorcontrib><creatorcontrib>Boruah, Paran</creatorcontrib><creatorcontrib>Borah, Jagat C.</creatorcontrib><creatorcontrib>Laisharm, Surbala</creatorcontrib><creatorcontrib>Moirangthem, Dinesh Singh</creatorcontrib><title>Synthesis of a novel series of fluoroarene derivatives of artemisinin as potent antifungal and anticancer agent</title><title>Bioorganic & medicinal chemistry letters</title><addtitle>Bioorg Med Chem Lett</addtitle><description>[Display omitted]
A series of new fluoroarene derivatives of artemisinin were prepared using Suzuki and Sonogashira cross-coupling reactions. An antifungal and antitumor activity was evaluated against opportunistic pathogen Fusarium oxysporum and Hela cancer cell line. All these derivatives have shown moderate to good activity.</description><subject>Anticancer</subject><subject>Antifungal</subject><subject>Antifungal Agents - chemical synthesis</subject><subject>Antifungal Agents - chemistry</subject><subject>Antifungal Agents - pharmacology</subject><subject>Antineoplastic Agents - chemical synthesis</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Artemisinin</subject><subject>Artemisinins - chemistry</subject><subject>Artemisinins - pharmacology</subject><subject>Cell Proliferation - drug effects</subject><subject>Cell Survival - drug effects</subject><subject>Fluorobenzenes - chemistry</subject><subject>Fluorobenzenes - pharmacology</subject><subject>Fusarium - drug effects</subject><subject>Fusarium oxysporum</subject><subject>HeLa Cells</subject><subject>Humans</subject><subject>Microbial Sensitivity Tests</subject><subject>Structure-Activity Relationship</subject><subject>Suzuki cross-coupling</subject><issn>0960-894X</issn><issn>1464-3405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAQhkVpaTZp_0APRcdevNG3bcilhHxBoIe20JsYy-NUi1faSvJC_n202aTHwIA077zzIj2EfOFszRk355v1sHXzWjCu16yWad-RFVdGNVIx_Z6sWG9Y0_Xqzwk5zXnDGFdMqY_kRBjW91rqFYk_H0P5i9lnGicKNMQ9zjRj8visTPMSU4SEAelY1T0Uvz-OIBXc-uyDDxQy3cWCoVAIxU9LeIC5Xsfn1kFwmCg81Pkn8mGCOePnl_OM_L6--nV529z_uLm7_H7fOCVMaaQcTdcCopGGOSOwl1KiVgqU0MyAbpkQqtfQqaHlU2s6GEQ3ahBSumFs5Rn5dszdpfhvwVxsfarDeYaAccmWm161lRjj1SqOVpdizgknu0t-C-nRcmYPoO3GHkDbA2jLaplD_teX_GXY4vh_5ZVsNVwcDVh_ufeYbHYeK4jRJ3TFjtG_lf8ESFqQEA</recordid><startdate>20150815</startdate><enddate>20150815</enddate><creator>Buragohain, Pori</creator><creator>Surineni, Naresh</creator><creator>Barua, Nabin C.</creator><creator>Bhuyan, Purnajyoti D.</creator><creator>Boruah, Paran</creator><creator>Borah, Jagat C.</creator><creator>Laisharm, Surbala</creator><creator>Moirangthem, Dinesh Singh</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150815</creationdate><title>Synthesis of a novel series of fluoroarene derivatives of artemisinin as potent antifungal and anticancer agent</title><author>Buragohain, Pori ; 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A series of new fluoroarene derivatives of artemisinin were prepared using Suzuki and Sonogashira cross-coupling reactions. An antifungal and antitumor activity was evaluated against opportunistic pathogen Fusarium oxysporum and Hela cancer cell line. All these derivatives have shown moderate to good activity.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>26099535</pmid><doi>10.1016/j.bmcl.2015.05.067</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0960-894X |
| ispartof | Bioorganic & medicinal chemistry letters, 2015-08, Vol.25 (16), p.3338-3341 |
| issn | 0960-894X 1464-3405 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Anticancer Antifungal Antifungal Agents - chemical synthesis Antifungal Agents - chemistry Antifungal Agents - pharmacology Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Artemisinin Artemisinins - chemistry Artemisinins - pharmacology Cell Proliferation - drug effects Cell Survival - drug effects Fluorobenzenes - chemistry Fluorobenzenes - pharmacology Fusarium - drug effects Fusarium oxysporum HeLa Cells Humans Microbial Sensitivity Tests Structure-Activity Relationship Suzuki cross-coupling |
| title | Synthesis of a novel series of fluoroarene derivatives of artemisinin as potent antifungal and anticancer agent |
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