Synthesis of a novel series of fluoroarene derivatives of artemisinin as potent antifungal and anticancer agent

[Display omitted] A series of new fluoroarene derivatives of artemisinin were prepared using Suzuki and Sonogashira cross-coupling reactions. An antifungal and antitumor activity was evaluated against opportunistic pathogen Fusarium oxysporum and Hela cancer cell line. All these derivatives have sho...

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Veröffentlicht in:Bioorganic & medicinal chemistry letters 2015-08, Vol.25 (16), p.3338-3341
Hauptverfasser: Buragohain, Pori, Surineni, Naresh, Barua, Nabin C., Bhuyan, Purnajyoti D., Boruah, Paran, Borah, Jagat C., Laisharm, Surbala, Moirangthem, Dinesh Singh
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Sprache:eng
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Zusammenfassung:[Display omitted] A series of new fluoroarene derivatives of artemisinin were prepared using Suzuki and Sonogashira cross-coupling reactions. An antifungal and antitumor activity was evaluated against opportunistic pathogen Fusarium oxysporum and Hela cancer cell line. All these derivatives have shown moderate to good activity.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2015.05.067