Anti-plasmodial activity of bradykinin and analogs

[Display omitted] To find effective new candidate antimalarial drugs, bradykinin and its analogs were synthesized and tested for effectiveness against Plasmodium gallinaceum sporozoites and Plasmodium falciparum on erythrocytes. Among them, bradykinin and its P2 analog presented high activity agains...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2015-08, Vol.25 (16), p.3311-3313
Hauptverfasser:	Silva, Adriana F., Alves, Flávio L., Pedron, Cibele N., Torres, Marcelo D.T., Silva, Leandro S., Pinheiro, Ana A.S., Miranda, Antonio, Oliveira, Vani X.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-plasmodial Antimalarials - chemical synthesis Antimalarials - chemistry Antimalarials - pharmacology Bradykinin Bradykinin - chemistry Bradykinin - genetics Bradykinin - pharmacology Humans Malaria Peptides Peptides - chemical synthesis Peptides - chemistry Peptides - genetics Peptides - pharmacology Plasmodium Plasmodium falciparum - drug effects Plasmodium gallinaceum - drug effects Sporozoites - drug effects
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Zusammenfassung:	[Display omitted] To find effective new candidate antimalarial drugs, bradykinin and its analogs were synthesized and tested for effectiveness against Plasmodium gallinaceum sporozoites and Plasmodium falciparum on erythrocytes. Among them, bradykinin and its P2 analog presented high activity against Plasmodium gallinaceum, but they degrade in plasma. On the other hand, RI-BbKI did not degrade and reached high activity. No analog was active against Plasmodium falciparum.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2015.05.071