Fungal toxins and health

The risk of ochratoxin A to human health was the subject of a recent meeting. Its toxicity was high-lighted in the 1970s when pigs in Denmark developed a nephropathy after eating mouldy feed containing ochratoxin A. Pig production is now handled in such a way as to limit ochratoxin A exposure by avo...

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Veröffentlicht in:	Trends in pharmacological sciences (Regular ed.) 1993-12, Vol.14 (12), p.424-426
Hauptverfasser:	Bach, Peter H., Bartsch, Helmut
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Humans International Cooperation Kidney Diseases - chemically induced Kidney Tubules - drug effects Ochratoxins - poisoning Ochratoxins - toxicity
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Beschreibung
Zusammenfassung:	The risk of ochratoxin A to human health was the subject of a recent meeting. Its toxicity was high-lighted in the 1970s when pigs in Denmark developed a nephropathy after eating mouldy feed containing ochratoxin A. Pig production is now handled in such a way as to limit ochratoxin A exposure by avoiding storing wet feed or reducing humidity where feeds will be stored for long periods. National programmes also assay ochratoxin A in feed, blood and meat, and contaminated material is condemned. Ochratoxin A causes proximal tubule necrosis and renal degeneration in all species (pig, dog, rat, rabbit, mouse, avians) tested. It is also teratogenic and immunosuppressive.
ISSN:	0165-6147 1873-3735
DOI:	10.1016/0165-6147(93)90175-J