Verongamine, a novel bromotyrosine-derived histamine H sub(3)-antagonist from the marine sponge Verongula gigantea

Verongamine, a novel bromotyrosine-derived histamine H sub(3)-antagonist from the marine sponge Verongula gigantea

The novel bromotyrosine derivative verongamine {1} has been isolated from the marine sponge Verongula gigantea. The isolation of verongamine was facilitated by employing histamine-H sub(3) bioassay-guided fractionation. Verongamine is a specific histamine-H sub(3) antagonist at concentrations as low...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of natural products (Washington, D.C.) D.C.), 1994-01, Vol.57 (1), p.175-177
Hauptverfasser: Mierzwa, R, King, A, Conover, MA, Tozzi, S, Puar, MS, Patel, M, Coval, S J, Pomponi, SA
Format: Artikel
Sprache:eng
Schlagworte:
Marine
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The novel bromotyrosine derivative verongamine {1} has been isolated from the marine sponge Verongula gigantea. The isolation of verongamine was facilitated by employing histamine-H sub(3) bioassay-guided fractionation. Verongamine is a specific histamine-H sub(3) antagonist at concentrations as low as 1 mu g/ml.
ISSN:0163-3864