Bactericidal/permeability increasing protein and host defense against gram-negative bacteria and endotoxin

The bactericidal/permeability increasing protein is a major element in the host defense against Gram-negative bacteria and endotoxin, acting intracellularly in the polymorphonuclear leukocyte. As an isolated protein, bactericidal/permeability increasing protein also acts as an extracellular bacteric...

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Veröffentlicht in:	Current opinion in immunology 1993-02, Vol.5 (1), p.103-107
Hauptverfasser:	Elsbach, Peter, Weiss, Jerrold
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimicrobial Cationic Peptides Blood Bactericidal Activity Blood Proteins - physiology Complement System Proteins - physiology Endotoxins - antagonists & inhibitors Endotoxins - toxicity Gram-Negative Bacteria Gram-Negative Bacterial Infections - immunology Humans Membrane Proteins Models, Biological Neutrophils - enzymology Neutrophils - physiology Phospholipases - physiology
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Beschreibung
Zusammenfassung:	The bactericidal/permeability increasing protein is a major element in the host defense against Gram-negative bacteria and endotoxin, acting intracellularly in the polymorphonuclear leukocyte. As an isolated protein, bactericidal/permeability increasing protein also acts as an extracellular bactericidal and endotoxin-neutralizing agent and, when injected, protects animals against lethal effects of Gram-negative bacteria and endotoxin.
ISSN:	0952-7915 1879-0372
DOI:	10.1016/0952-7915(93)90088-A