Immune response triggered by Brucella abortus following infection or vaccination

Immune response triggered by Brucella abortus following infection or vaccination

Highlights • Coordinated action of CD4+ and CD8+ T-cells confers resistance to B. abortus. • IFN-γ, Tc1 CD8 and Th1 CD4 T-cells are major immune mechanisms against B. abortus. • IFN-γ is the central cytokine in the immune response against B. abortus. • Protection given by B. abortus vaccines is rela...

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Veröffentlicht in:Vaccine 2015-07, Vol.33 (31), p.3659-3666
Hauptverfasser: Dorneles, Elaine M.S, Teixeira-Carvalho, Andréa, Araújo, Márcio S.S, Sriranganathan, Nammalwar, Lage, Andrey P
Format: Artikel
Sprache:eng
Schlagworte:
Abortion
Allergy and Immunology
Animals
Bovine brucellosis
Brucella abortus - immunology
Brucella Vaccine - administration & dosage
Brucella Vaccine - immunology
Brucellosis
Brucellosis vaccines
Brucellosis, Bovine - immunology
Brucellosis, Bovine - prevention & control
Cattle
Conflicts of interest
Cytokines
Cytotoxicity
Endoplasmic reticulum
Immune response
Immunity, Cellular
Immunity, Humoral
Infections
Mice
Milk
RB51
S19
Vaccines
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Zusammenfassung:Highlights • Coordinated action of CD4+ and CD8+ T-cells confers resistance to B. abortus. • IFN-γ, Tc1 CD8 and Th1 CD4 T-cells are major immune mechanisms against B. abortus. • IFN-γ is the central cytokine in the immune response against B. abortus. • Protection given by B. abortus vaccines is related to a strong Th1 immune response.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2015.05.057