The genetics of lipid storage and human lipodystrophies

Highlights • In vertebrates, adipocytes store surplus energy within a large unilocular lipid droplet. • Lipid accumulation in non-adipose tissue is seen when adipose tissue is impaired. • Insulin resistance is strongly associated with ectopic lipid accumulation. • Matching energy intake with adipose...

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Veröffentlicht in:	Trends in molecular medicine 2015-07, Vol.21 (7), p.433-438
Hauptverfasser:	Robbins, Ann L, Savage, David B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - metabolism ectopic fat Humans insulin resistance Insulin Resistance - physiology lipid droplet lipodystrophy Lipodystrophy - epidemiology Pathology
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Beschreibung
Zusammenfassung:	Highlights • In vertebrates, adipocytes store surplus energy within a large unilocular lipid droplet. • Lipid accumulation in non-adipose tissue is seen when adipose tissue is impaired. • Insulin resistance is strongly associated with ectopic lipid accumulation. • Matching energy intake with adipose capacity alleviates this metabolic stress.
ISSN:	1471-4914 1471-499X
DOI:	10.1016/j.molmed.2015.04.004