Copper(II)-promoted direct conversion of methylarenes into aromatic oximes

Copper(II)-promoted direct conversion of methylarenes into aromatic oximes

A simple and efficient catalytic system for direct conversion of methylarenes into aromatic oximes has been developed, with Cu(OAc)2 as catalyst, NHPI (N-Hydroxyphthalimide) as additive, TBN (tert-butyl nitrite) as both the nitrogen source and the oxidant. This process proceeds under mild conditions...

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Veröffentlicht in:Organic & biomolecular chemistry 2015-07, Vol.13 (27), p.7397-7401
Hauptverfasser: Yu, Jiatao, Lu, Ming
Format: Artikel
Sprache:eng
Schlagworte:
Copper - chemistry
Hydrocarbons, Aromatic - chemical synthesis
Hydrocarbons, Aromatic - chemistry
Ketones - chemistry
Oximes - chemical synthesis
Oximes - chemistry
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Zusammenfassung:A simple and efficient catalytic system for direct conversion of methylarenes into aromatic oximes has been developed, with Cu(OAc)2 as catalyst, NHPI (N-Hydroxyphthalimide) as additive, TBN (tert-butyl nitrite) as both the nitrogen source and the oxidant. This process proceeds under mild conditions, tolerates a wide range of substrates, affording the targeted aromatic oximes in 63-86% yields.
ISSN:1477-0520
1477-0539
DOI:10.1039/c5ob00923e