Direct Reprogramming of RESTing Astrocytes

Understanding the mechanisms underlying neuronal fate determination will provide important insights into brain development and regenerative approaches to neurological diseases. Now in Cell Stem Cell,Masserdotti et al. (2015) use neuronal conversion of astrocytes to dissect transcriptional mechanisms...

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Veröffentlicht in:	Cell stem cell 2015-07, Vol.17 (1), p.1-3
Hauptverfasser:	Wang, Chengzhong, Fong, Helen, Huang, Yadong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Astrocytes - cytology Astrocytes - metabolism Cellular Reprogramming - physiology Humans Repressor Proteins - metabolism
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Understanding the mechanisms underlying neuronal fate determination will provide important insights into brain development and regenerative approaches to neurological diseases. Now in Cell Stem Cell,Masserdotti et al. (2015) use neuronal conversion of astrocytes to dissect transcriptional mechanisms of fate determination and identify circuits that mediate cellular identity. Understanding the mechanisms underlying neuronal fate determination will provide important insights into brain development and regenerative approaches to neurological diseases. Now in Cell Stem Cell, Masserdotti et al. (2015) use neuronal conversion of astrocytes to dissect transcriptional mechanisms of fate determination and identify circuits that mediate cellular identity.
ISSN:	1934-5909 1875-9777
DOI:	10.1016/j.stem.2015.06.011